Mancini doesn't have a full squad to choose from but must go on the attack from the start in an attempt to put more pressure on United's creaking defence. Craig Bellamy is in the form of his life along with Carlos Tevez, who will be desperate to impress against his former club. Both should start, while Stephen Ireland can also offer extra threat going forward.
Unlike Ferguson's, Mancini's options are favourable and he must make the most of home advantage, provided he can resolve his defensive issues caused by injuries and international commitments.
Injury Update: Nedum Onuoha, Joleon Lescott and Wayne Bridge remain long-term absentees, while Kolo Toure is on international duty at the African Cup of Nations. Shaun Wright-Phillips (knee) and Roque Santa Cruz (knee) will have late fitness tests. Mancini could keep faith with Dedryck Boyata after the Belgium under-21 international impressed on his debut at Middlesbrough last weekend.